Metathesis

Written by Dr Will Watson on Wednesday, 06 August 2014. Posted in Process Chemistry News

Specialised Session at Modern Synthetic Methods & Chiral USA, Orlando May 2014.

The session consisted of 5 presentations which are summarised below with the summaries concentrating specifically on the metathesis reactions presented, although several speakers also described some very interesting chemistry used to make the metathesis substrates.

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Hydrogen Atom Transfer to Deliver Thermodynamically Preferred Product

Written by Dr John Knight on Monday, 19 May 2014. Posted in Process Chemistry News

Heterogeneous catalytic hydrogenation is of course a much-used chemical reaction and very efficiently delivers product with high atom economy.  The chemo- and stereoselectivity has been studied many times over the years and is in general fairly predictable based on steric impediment and the ability of the substrate to approach the catalyst surface for hydrogen transfer.

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Benzylic Hydroxyl Cleavage with Trimethylsilyl Iodide

Written by Dr John Knight on Monday, 19 May 2014. Posted in Process Chemistry News

Looking at OPRD, as I scan through the various reaction schemes, some steps catch my attention, not least because I consider the mechanistic steps of reactions I don’t recognise.  While looking at the article by Yamagami et al (OPRD, 2014, 18, 437) I saw the cleavage of a benzylic hydroxyl using TMS-Cl/NaI in acetonitrile.

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Living Up To The Process Challenge

on Wednesday, 02 April 2014. Posted in Process Chemistry News

C&EN Volume 92 Issue 12 | pp. 30-33 Issue Date: 24 March 2014

In a typical day, process chemists select reagents, pore over synthetic routes, think about safety, and manage costs.

Eli Lilly & Co. process chemist David Mitchell’s wife, Pearlette, doesn’t always like it when he pulls out his smartphone to check the latest journal e-alert. He never knows if the latest paper to hit his in-box will contain a solution he needs for an efficient new kilogram-scale synthesis of a drug candidate. So anytime his pocket buzzes, Mitchell takes a look.

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