ADME and hERG in Medicinal Chemistry
In addition to maintaining their sound synthetic organic chemistry knowledge, Medicinal Chemists have to address complex ADME (Absorption, Distribution, Metabolism and Elimination) and pharmacology issues on a day to day basis.
Although relevant principles of pharmacology can be picked up from traditional medicinal chemistry books, much of the wisdom required to progress projects takes years to acquire and many ‘tricks of the trade.’ These are often concealed within a profusion of medicinal chemistry papers.
Distilling practical help from the literature itself requires experience as well as time. ‘ADME - hERG – Succeed through the Literatur
