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Training Courses

Event 

Title:
Biocatalysis as a Tool for the Synthetic Chemist
When:
29.10.2013 - 30.10.2013
Tutors:
Where:
Hotel Fira Palace - Barcelona
Brochure:
View Brochure

Description

The aim of the course is to give organic chemists an understanding and an overview of the subject of biotransformations. Attendees will learn about the main classes of enzymes and the transformations these enzymes carry out. Each transformation type will be illustrated with examples and case studies and the course will also include problem sessions where attendees will work on real examples applying biotransformations to organic synthesis. Recent developments in the field will be covered as well as an overview of the sort of equipment and resources required.

  • Who Should Attend?
  • Outline
  • Testimonials

  • Any Organic Chemist involved in synthesis, particularly those involved in designing novel, green synthetic routes.

    Chemists who want to learn how biocatalysis can help them.

    Those involved in the scale up of biocatalytic reactions.

  • Introduction to Biocatalysis

    Literature sources for biocatalysis (books and review articles)
    Myths about biocatalysis / pros and cons of biocatalysis
    Enzyme / protein basics, basic microbiology
    Sources of biocatalysts
    Equipment requirements
    Enzyme types

    Hydrolytic Enzymes (Lipases, esterases, amidases, proteases)

    Mechanism of hydrolysis by enzymes
    Kinetic resolution
    Use of organic solvents
    Dynamic kinetic resolution (DKR)
    Deracemisation
    Ester, amide, nitrile and epoxide hydrolysis concentration

    Oxidations

    Alcohol oxidation
    Amine oxidation, deracemisation of amines and amino acids
    Bio-oxygenation, bio-hydroxylation
    Demethylation
    Epoxidation
    Bayer-Villiger oxidation
    Sulphoxidation

    Reduction

    Ketone reduction, Prelog rules
    Co-factors
    Deracemisation of secondary alcohols
    Enantioselective reduction / DKR
    Keto-ester reduction
    C=C reduction

    C-C and C-X bond formation

    Aldol reactions
    Transketolases
    Cross benzoin reactions
    Hydroxy-nitrile lyases
    Michael reactions
    Transamination
    Fumarase and aspartase

    Scale Up of Biotransformations

    Reactors
    Case studies

    New Developments including Directed Evolution

    Polymerase Chain Reaction
    Mutagenesis
    Directed Evolution
    Product isolation

    Pros and Cons of Biocatalysis

    Summary
    Q&A, discussion

  •  “ Very good course, well presented ..."
    JODY BAKER, COGNIS UK LTD

Fee Info

Course Fee:
£1075
Multi Discount:
SAVE 5% for 2 attendees and 15% for 3 attendees

Venue

Hotel Fira PalaceMap
Venue:
Hotel Fira Palace   -   Website
Street:
Avda Rius I Taulet, 1-3
Postcode / ZIP:
08004
City:
Barcelona
Country:
SP

Description

Hotel Fira Palace is an elegant contemporary hotel, centrally located in downtown Barcelona, right next to the well known Plaza España, and a short distance away from the famous Ramblas and the sea front.

The Hotel Fira Palace offers you the largest bedrooms in the city, a restaurant which serves exquisite regional and international cuisine and excellent leisure facilities.

The hotel is holding standard rooms for us at a discounted rate. Scientific Update is contractually obligated to certain financial goals with the hotel.  Your reservation is greatly appreciated, as it helps to meet our agreement.  Please make your reservation soon in order to secure the reduced group rate.

Directions:

From El Prat Airport it takes between 15/20 minutes to reach the hotel by Taxi.  There is also a special Aerobus service which stops at various places in the city - the stop you require is Plaza Espana, which is a 5 minute walk from the Fira Palace. Tickets can be purchased on the bus.